DKMS stands for ‘Deutsche Knochenmarkspenderdatei’, or German Bone Marrow Donor Center. But as we became more international, we extended our mission to include Poland, the US, the UK, Chile, India and South Africa.
BMST stands for 'Bangalore Medical Services Trust'. BMST is a non-profit organization of the Rotary Club of Bangalore and TTK group of companies. Founded in 1984 it was initially set up to provide blood-banking services through its division, the Rotary Bangalore-TTK Blood Bank.
The DKMS group is the world’s largest international network of donor centers and grows steadily every year. Inspired by our mission of providing every blood cancer and blood disorder patient with a matching blood stem cell donor we work with passion, enthusiasm and dedication. We work together to promote the sharing of ideas and always encourage creativity. A team in the truest sense of the word, we support each other to achieve our goals. We value diversity and strive to reflect the communities we serve. Our people are at the core of everything we do, together we help give blood cancer & blood disorder patients a second chance of life.
We value diversity and inclusion and are committed to the principles of equal employment opportunity. We comply with all applicable laws prohibiting discrimination or harassment against any applicant or employee. This prohibition includes, without limitation, discrimination based on age, ethnicity, external appearance, gender, national origin, religion, creed, genetic information, sexual orientation, gender identity, pregnancy, childbirth or related medical conditions, marital status, citizenship status, and any other personal characteristic protected by applicable law.
In the fight against blood cancer, we are always looking for the best possible people to join our team!
DKMS-BMST offers a wide range of job opportunities. We need employees for various positions, such as for our donor recruitment, donor request management, data management, IT, accounting, administration, marketing, fundraising & events, and press departments.
We are always keen to meet energetic and talented professionals who would like to join our team. If you wish to be considered for any future positions, you can also send your CV and cover letter to email@example.com
When you register as a potential blood stem cell donor, you receive a DKMS-BMST donor card. This will contain your personal DKMS-BMST donor number. It makes our work easier if you keep the donor card close to hand and state your donor number when we contact you.
'Blood cancer' is the umbrella term used for a variety of malignant diseases of the blood-forming (hematopoietic) system. A distinction is made between two kinds, depending on how they originated: leukemias and lymphomas. Leukemias begin in the bone marrow, whereas lymphomas start in the lymphatic system. All blood cancers involve the degeneration of certain blood cells, which multiply uncontrollably and suppress the healthy blood-forming system. This prevents the blood from performing vital functions, such as fighting infections, transporting oxygen or stopping bleeding.
The three most common forms of blood cancer are:
DKMS regularly launches new projects to enhance the quality of donor typing and to expand typing profiles. This allows us to improve the quality of the data we have, even for donors who have been registered with us for a long time, because you never know when a donor will match with a patient. If we find we need more information, we contact the donors concerned and ask them to provide a new sample, usually by a regular cheek swab, like when someone registers as a new donor.
DKMS contacts selected donors by post and email as part of the following quality projects:
When DKMS contacts you as part of any of these projects, there is no specific patient involved. We are merely proactively assessing further parameters, to improve the quality of our data, which means that we can improve the speed of donor searches, because for a patient looking for a match, sometimes every day counts!
HLA characteristics are the most important factor in identifying a matching donor. In order for a stem cell transplantation to have the highest chance of success, ideally 10 out of 10 relevant HLA characteristics should match between the patient and the donor. If a patient is fortunate enough to have several matches, other factors will be analyzed to find the optimal match. This is why we test more than 10 HLA characteristics. As part of the initial typing, we also tissue type for further parameters that could prove advantageous, either now or in the future, such as the entire KIR receptor family, MICA/B, CCR5, HLA-DPB1, HLA-E, HLA-DQA1, HLA-DPA1, HLA-DRB3/4/5 and the ABO and Rh blood groups. In addition, our donors are also tested for cytomegalovirus (CMV), a common herpes virus. All of these markers are currently typed at high-resolution when someone registers as a donor.
At DKMS, we use cutting-edge science to continuously expand the typing profiles of donors and to meet or define state-of-the-art standards in technology and medicine. That way, we ensure constant enhancements and even more precision in donor selection. All of these quality improvements are crucial for the benefit of patients.
All the samples we receive are typed at the DKMS Life Science Lab located in Dresden, Germany. The lab is a world leader in HLA diagnostics and accredited to international standards. In 2013, the DKMS Life Science Lab became the first HLA-typing lab in the world to introduce the new sequencing technology NGS (Next Generation Sequencing), for high-parallel, high-throughput typing.
Tissue characteristics vary from person to person – but they are also different between ethnicities. So when it comes to finding a matching donor, a person’s ethnic background is important. Blood cancer, on the other hand, can happen to anyone. So we need as many people as possible with the widest possible variety of genetic characteristics to register in our database. A donor with the same ethnic background as a patient may be a better match than one who comes from an entirely different background.
If you register with DKMS-BMST as a potential blood stem cell donor, one of the questions we ask you will be about your ethnic background. This information allows us to better organize our database. This could make it easier and faster for doctors to search for a matching donor for their patient.
For blood stem cell transplants, what matters is not so much the same blood group but the best possible match between the tissue characteristics from the donor and patient. A perfect match is very complicated to find and much like looking for a needle in a haystack. When blood stem cells are transplanted, the recipient acquires the same blood group as the donor.
At most, your blood group would be an additional factor in your selection.
As the world’s largest network of blood stem cell donor centers, DKMS-BMST has a special responsibility to protect the personal and especially sensitive medical data that registered donors entrust to us. We take data privacy very seriously. It goes without saying that we fully comply with the statutory requirements of the EU’s General Data Protection Regulation (GDPR), but we have also committed to an even higher level of data privacy.
Your personal details are only handled by DKMS-BMST and our appointed service providers. Our commissioned data processing (CDP) agreements with service providers ensure they are all committed to upholding our highest data privacy standards. The data relevant to the stem cell donor search, such as HLA tissue characteristics, age, and gender, is always pseudonymized before we send it to World Marrow Donor Association (WMDA). This means that doctors and transplant centers searching the database for a matching donor are only able to see this information and your personal information remains only with DKMS-BMST.
Based in Dresden, Germany the DKMS Life Science Lab GmbH (LSL) is one of the world’s largest and most advanced genotyping laboratories focusing on high-resolution HLA typing for stem cell donor registers. Over 100,000 donor samples a month can be analyzed there.
From the outset, LSL has aimed to incorporate the latest scientific findings and developments into the standard typing process. This has led to the typing profile being extended beyond the standard HLA characteristics to include numerous additional parameters (e.g. ABO, RhD, CCR5, KIR, HLA-E, MICA/B, and CMV IgG).
When fast action is needed, this is the best and quickest way to check whether – and how well – a potential blood stem cell donor matches a blood cancer patient. Thanks to our high-quality typing, search times have decreased, while the chances of a successful transplant have increased.
The DKMS Life Science Lab employs cutting-edge biotechnology procedures. In 2013, for instance, it was the first HLA-typing laboratory in the world to introduce the new NGS technology (Next Generation Sequencing), for high-throughput typing. Today, well over a million potential blood stem cell donors a year are typed using this procedure.
Attached to the DKMS Life Science Lab are a clinical laboratory for patient-based typing or confirmatory typing (CT), and a clinical search unit accredited by the ZKRD (German National Bone Marrow Donor Registry). For more information please visit www.dkms-lab.de
In most cases, blood stem cell transplants are used for patients who have a disorder of the blood-forming system, such as any form of leukemia and lymph node cancer in children and adults, severe aplastic anemia, severe congenital immune defects (in children only), and various disorders of the red blood cells. But the most common reason for a blood stem cell transplant is to treat one of several types of blood cancer.
After two to four weeks, an increase in the patient’s white corpuscle count offers an initial indication that the new blood stem cells are doing their job and creating healthy blood cells. If the corpuscles continue steadily increasing, the outlook for the patient improves. The success of the therapy is affected by a range of factors, such as the type of basic illness, the stage at which it was diagnosed and treated with a transplant, the age and general fitness of the patient, possible accompanying illnesses, type of conditioning, and the closeness of the match between patient and donor tissue characteristics.
The doctors will try to treat the patient by alternative means, possibly with radio- or chemotherapy, depending on the illness. For many patients, however, a blood stem cell transplant from a matching donor is the only treatment offering any hope of a cure.
Any adult between the ages of 18 and 50 and in general good health can become a donor. If you are already registered with any blood stem cell registry, it is not necessary to sign up again. If you suffer or have suffered from a chronic illness or any other severe illness or regularly take medication, please discuss your case with DKMS-BMST.
Key conditions that do not prevent you from becoming a blood stem cell donor:
An enlarged or underactive thyroid, Hashimoto’s thyroiditis (You must be stable and symptom-free, even if you are taking thyroid hormones or iodine. However, you cannot donate if you have Graves’ disease)
An enlarged thyroid gland is often caused by a lack of iodine (iodine deficiency goiter), but it can also be attributed to a lack of thyroid hormones – because a thyroid gland forms increasing amounts of tissue as it attempts to compensate for insufficient hormone production. If you do not have any symptoms and your thyroid medication is properly balanced, there is no reason you cannot become a blood stem cell donor.
If the hypothyroidism is caused by thyroid surgery, there is also nothing to prevent you from joining our register — unless the intervention was for Graves’ disease or thyroid carcinoma.
If the hypothyroidism is caused by an autoimmune disorder of the thyroid gland (Hashimoto’s thyroiditis), you may only be able to donate blood stem cells via a bone marrow collection from the pelvic bone. This point will be clarified if you are identified as a possible match for a patient.
If the hypothyroidism is caused by something other than a pre-existing thyroid condition, you can still sign up as a donor.
Morbus Hashimoto is one of the few autoimmune diseases that are not a major problem in blood stem cell donors. However, the thyroid gland must be properly regulated with medication. In addition, some people with the disorder may at times only be able to donate through a bone marrow collection from the pelvic bone. This point will be clarified as soon as you are identified as a possible match for a patient.
Graves’ disease is an autoimmune disorder of the thyroid gland that causes excessive thyroid production (hyperthyroidism). This can be problematic for both donor and recipient.
As a rule, high blood pressure is not an issue when it comes to donating stem cells — but it must be well regulated by diet or medication, and not have damaged the eyes, heart, or blood vessels. If your blood pressure is well-regulated, you can register as a stem cell donor.
Allergies (including food and medication allergies, and hay fever) are not a problem for potential donors — unless they have previously experienced severe allergic reactions (e.g. allergic shock, Quincke’s edema). Please advise us if you have had severe reactions, as it could affect your suitability as a donor.
As with many other conditions, what matters is the severity of depression or anxiety. The first thing to do is to find out whether the condition restricts you in any way, and check your general resilience — because donating blood stem cells is an additional mental strain for donors.
The question here is not so much whether a donor will reliably show up at the stem cell donation center but whether they can handle the situation afterward. After all, donating stem cells effectively means you gain a severely ill ‘blood relative’, and many of our donors are very concerned about the wellbeing of their recipient.
The use of psychotropic drugs also poses a particular problem, as they affect the blood count. Neuroleptics especially will prevent you from becoming a potential stem cell donor. Other conditions precluding registration as a stem cell donor include mental illnesses requiring treatment, such as severe depression, borderline syndrome, and any form of psychosis, schizoaffective disorder or bipolar/manic affective disorder.
Slight depression that requires only limited treatment is not an issue, as long as the donor feels fit enough to cope with everyday life. Anyone medicating with less problematic ingredients, such as Citalopram or Fluoxetine, can also still sign up as a stem cell donor.
The most important exclusion criteria are:
DKMS-BMST is legally obligated to comply with the international medical exclusion guidelines for blood stem cell donors.
To register with us or to donate blood stem cells, your body mass index (BMI) must not be over 40 – for various reasons.
For people in general good health, donating blood stem cells does not have any significant risks. However, for people with additional risk factors, there may be some health concerns. Unfortunately, obesity is one such risk factor.
Severe obesity poses a problem because it leads to a degree of risk for the donor with both types of blood stem cell collection procedures. Not only is the anesthetic risk higher with bone marrow donations, but with peripheral blood stem cell collection, it is also difficult to gauge precisely how much medication is needed, which may increase the chances of side-effects.
The health and safety of our donors is our number one priority and the weight limits are in place purely for the protection of our donors.
If you have diabetes mellitus type 1, registering as a potential donor is unfortunately not possible due to health concerns for both you and the potential recipient.
Blood stem cells are a part of the immune system, which means that a donation from a type 1 diabetic could mean that the condition is passed on to the recipient. As the patient’s health is already compromised, it is difficult to predict how their condition might develop. Serious complications would be likely to occur.
In addition, increased blood sugar levels may already have damaged the donor’s nerves and blood vessels to varying degrees, and donating blood stem cells could compromise their health even further.
With diabetes mellitus type II, or type 2 diabetes, some cells become resistant to insulin. This prevents them from absorbing sufficient glucose from the bloodstream. Increased blood sugar levels may already have damaged nerves and blood vessels to varying degrees. Donating blood stem cells could compromise their health even further – so again, we cannot include anyone with type 2 diabetes as a potential blood stem cell donor.
Rheumatoid conditions, even when there are no symptoms, are another factor preventing people from registering. They include rheumatoid arthritis, Bekhterev’s disease, and juvenile arthritis, all of which are autoimmune diseases and therefore mean that unfortunately, you cannot register as a blood stem cell donor.
A stem cell transplant involves the transfer of cells from the immune system, and if the donor’s immune system is damaged, it will have adverse effects on the recipient, compromising their health.
(including former patients who have been given the all-clear)
Unfortunately, anyone who has previously had a malignant condition is not able to donate blood stem cells.
If you have ever had a malignant growth (or, to be more precise, one that is not specifically benign) you cannot donate blood or stem cells — no matter how long ago the illness was or how successful the therapy was.
(alcohol, drugs, medications)
Occasional marijuana/cannabis consumption is not an issue – although the emphasis here is on the word ‘occasional’.
This is in part because regular drug use raises the question of reliability. It is not that a donor who takes drugs would be any more likely to suffer any complications, but unreliability is extremely problematic. The timing and scheduling of blood stem cell donations and transplants are crucial to the survival chances of the patient.
For you to register, we need to know what drugs you take and for how long you have been taking them. If you have been consuming them for a long time, it might be better not to register, but if you are ready and able to quit, then you are welcome to join us as a potential blood stem cell donor.
High blood pressure that is successfully regulated or a mitral valve prolapse with no further symptoms do not affect your ability to become a blood stem cell donor. The same goes for people with an unusually high or low resting pulse rate: as long as it is regular, that is all that matters.
However, with most other cardiovascular conditions, requiring treatment or monitoring, the risk of complications when donating blood stem cells is significantly higher. This means that anyone suffering from conditions such as cardiac arrhythmia, damaged vascular walls, arteriosclerosis (especially if blood thinners are needed), heart attacks, strokes, or structural damage to the heart (such as valve defects) is not able to register as a potential blood stem cell donor.
Another factor that would definitely prevent you from donating blood stem cells is frequent or prolonged breathlessness.
If you are being treated for any other conditions, please contact us to check if you can still become a blood stem cell donor.
If you have a heterozygous Factor V Leiden mutation (APC resistance), you can join our register – as long as it can be confirmed that you do not have any further clotting disorders or an increased risk of thrombosis linked to smoking, the contraceptive pill, being overweight, etc and you have not previously suffered from thrombosis.
If the mutation is homozygous, unfortunately, we cannot allow you to register as a donor.
If you have a serious, life-threatening infection such as HIV and if there is no way of proving that you are fully cured (e.g. hepatitis C), we cannot allow you to donate blood stem cells, primarily for the protection of the recipient.
Disorders of the blood and immune system are problematic because blood stem cells for transplantation come from the blood-forming and immune systems. To minimize the risk to recipients, both of these systems should be working as normally as possible. When blood stem cells are transplanted, acquired disorders can potentially be transplanted with them, as the cells for transplant contain mature cells of the immune system. In addition, some blood disorders can pose an increased risk to the donor: problems with clotting factors, for example, can cause thrombosis or bleeding.
If you are already registered with any other registry in the country where you are living, you should not re-register. We, and each of these organizations, list the relevant information of our donors with the World Marrow Donor Association (WMDA), so re-registering would lead to duplication, confusion and a waste of resources.
You can still register with us as a potential blood stem cell donor during your pregnancy as long as you fulfill the other requirements for donor suitability. Please let us know whether you are pregnant and what your due date is. From this time and generally, one year after the birth (nursing and recovery time), you will not be able to donate your blood stem cells. After this period has ended, you will once again be able to be matched with a patient searching for an unrelated donor unless we hear otherwise from you.
As part of your registration with DKMS-BMST, your tissue characteristic combinations will be examined. However, no tests for specific infections are carried out. Since specific requests for a blood stem cell donation may not be made until years later, we do not examine you for specific infections such as HIV, Hepatitis B and C, until you are actually being considered as a donor.
Yes. “On 6 September 2018, the Supreme Court of India issued its verdict. The Court unanimously ruled that Section 377 is unconstitutional as it infringed on the fundamental rights of autonomy, intimacy, and identity, thus legalizing homosexuality in India.”
In many cases, a blood stem cell transplant is the only chance of a cure for patients with blood cancer, such as Leukaemia, Lymphoma and Myeloma and blood disorders such as Thalassemia and Aplastic Anaemia.
When a potential donor registers with us, the samples are sent to the DKMS Life Science Lab in Dresden, Germany for testing. At the lab, the sample is analysed to determine the HLA (Human Leukocyte Antigens) characteristics – a fairly complex procedure which can take up to six weeks. After the HLA has been typed, the data is stored confidentially and made available in an anonymous form via the DKMS registry and registries around the world, via the World Marrow Donor Association. Transplant physicians search these registries for matching donors for their patients. Only donor ID, Gender, date of birth and HLA characteristics are shared with the registries. Once you are on the registry, you will be informed and will receive a welcome email from us.
When you register with DKMS-BMST, you are added to the DKMS registry. Your data is stored confidentially and you could match with a patient anywhere in the world. Registering is a serious commitment that requires you to be willing to donate to any patient in need. If you only want to see if you can donate to a particular person, you must be tested privately through the patient’s transplant doctor.
The safety of all of our donors is our main priority. The age limit is not intended to discriminate. Medical guidelines have been established to protect the safety of the donor and provide the best possible treatment to the patient. Additionally, research shows that cells from younger donors lead to a more successful outcome for the patients.
Ethnic heritage is a very important factor. A patient is most likely to find a matching donor who has the same ethnicity because people from the same ethnic group are more likely to have the same tissue traits. With more than 25,000 known HLA characteristics that can occur in millions of combinations, finding a match is extremely rare. Patients of more diverse ethnic backgrounds also tend to have more diverse HLA types, making it even more difficult to find a match.
When you register with DKMS-BMST, you are making yourself available as a potential blood stem cell donor for a patient in need of a transplant. You will only be asked to donate if you match with a patient. You will then be asked to donate blood stem cells in a procedure that is similar to donating blood platelets. You can remain a regular blood donor after registering as a stem cell donor, however if you do match with a patient, we ask that you don’t give blood for a month prior to donation and for a few months after.
Looking for a matching stem cell donor is like looking for a needle in a haystack. When a blood cancer or blood disorder patient depends on a blood stem cell transplant to survive, they need a donor whose tissue characteristics are a 100% match, if possible. Search requests are sent to the World Marrow Donor Association (WMDA), and if a potential donor is found on the DKMS-BMST database, to match the patient, we will be informed and we will then contact the donor immediately.
Before any donation takes place, you will be asked to fill out a detailed health questionnaire so that we can make sure early on that you are still suitable as a donor. You will then be asked for a blood sample, which will go for confirmatory typing. Your regular GP will be able to take the blood sample. Your blood will also be checked for other infections, such as HIV or hepatitis viruses. The results of your blood tests will be used to decide whether you really are the best match for the patient.
In about 80 percent of cases, stem cells are taken from the bloodstream. This procedure does not require anaesthetic or admission to hospital. During the collection, a sterile needle will be placed into a vein in each of your arms. Blood is drawn through one vein and passed through a machine that collects the stem cells, before the rest of the blood is returned back into the body through the other arm. It is similar to a blood donation and it is normally completed within 4-6 hours. Occasionally a subsequent donation may be required on the following day.
For the five consecutive days leading up to the donation, the growth factor G-CSF, which is naturally present in the body, is injected subcutaneously to the donor. This is required in order to increase the number of stem cells in the blood. The donor may experience some temporary discomfort, (for example headache, body ache, fatigue, nausea) while they are receiving G-CSF. These symptoms disappear within a day or two following the donation and donors can take non-aspirin products (such as Paracetamol or Ibuprofen) for relief from the discomfort.
Our donors are our number one priority so it goes without saying that we will do everything that we can to meet your wishes – but for some patients, one particular collection method could be the preferred option. This decision is made by the patient’s physician. So ideally, you should be happy to undergo either collection procedure.
Which procedure is actually carried out depends first and foremost on the needs of the patient. Bone marrow and peripheral blood both contain the blood stem cells that are needed, but in different quantities and in combination with other immunological cells with different activities.
Anyone who makes a blood stem cell donation for the benefit of other people or society as a whole, is covered by statutory accident insurance. This is legally required and covers anyone donating blood or tissue. If you are donating blood stem cells, you do not need to take out any extra insurance, as you will also be covered by this insurance. In addition, this insurance policy also covers the outpatient blood stem cell collection (PBSC), as well as your travel to and from the collection center.
Some people donate stem cells on more than one occasion, either to the same patient or to different ones. If you have blood stem cells removed, new ones will be generated to replace them, in much the same way as your blood is replaced when you make a blood donation. So it is possible to donate more than once. However, to minimize the strain on donors as far as possible, we try to keep those that have made a donation as backups, just in case their patient has a relapse and more blood stem cells are needed. We also use our Replacement Donor Program to prevent multiple donations. This identifies donors with identical combinations of tissue characteristics so we have a backup for each one.
If you are donating blood stem cells via the PBSC method, the G-CSF medication you will receive will not affect your ability to work. However, you will need to take time off work for your medical examination, plus another two days for the blood stem cell collection. You will not need any more time off work after that. If after the donation you happen to become sick, your regular GP will be able to issue a sick certificate for you.
In our experience, the vast majority of employers respond positively to the news that one of their staff is being invited to donate blood stem cells. If you are not covered by your employer, DKMS-BMST has a financial assistance program, that deals with lost wage compensation.
After a blood stem cell donation, the body quickly regenerates the level of blood stem cells to what they were before the donation. The process is comparable to a blood donation and does not lead to a permanent loss of blood stem cells. The donor’s own immune system will not be weakened.
If the patient’s country allows it, we can request an update on their state of health at least three months after the transplant was carried out. In our experience, there is no way of knowing how long it will take for a reply to reach us. If you want to hear about your patient, you will normally be contacted by DKMS-BMST.
International guidelines stipulate that donors and patients may only meet each other in person two years after the donation, which is additionally dependent on the regulations in the patient’s country of residence. Some countries do not allow any contact. In the meantime, if allowed by the regulations in the patient’s country; donors can contact patients anonymously, sending letters or gifts via DKMS-BMST. Due to privacy reasons, DKMS-BMST has no direct contact with patients and often has only a minimal influence on the forwarding of mail to patients. Here, we depend on the support of the hospital treating the patient. Since patients often receive further treatment from another clinic or hospital after the transplantation, delays may occur. After the end of the two-year period, donors and patients may write to each other directly or meet each other in person – again mediated by DKMS-BMST provided both parties agree. Experience over the years has shown that many donors and patients want to get to know each other. Time and time again, meetings between donors and patients are very moving moments. It is not uncommon for lasting friendships to develop.
If you have any other questions, our Donor-Patient Contact department will be happy to help: firstname.lastname@example.org
Tissue characteristics are hereditary, so the chances of finding a matching donor are highest within the patient’s family. About 30 percent of patients find a family member who has the tissue characteristics they are looking for.
Children inherit half of their tissue characteristics from their mother and half from their father. This means that parents are normally only haploidentical, or ‘half-matching’ donors. The highest probability of a match is between siblings, which is why they are the first family members to be tested as potential donors.
If a patient requiring a transplant has siblings, they will be the first to be tested. With young patients, the parents are typed as well. The age and state of health of the various family members is crucial. If no matching donor can be found among the patient’s immediate relatives, the search begins for a compatible unrelated donor in databases around the world.
On being identified as a match for a patient, you may withdraw from making a donation, at short notice, for personal or other reasons. Please note that we respect your decision, regardless. However, if you withdraw your commitment shortly before the actual transplantation, the doctors would have already initiated the patient’s preparation phase for the blood stem cell transplantation and at this point in time, the patient cannot survive without the transplantation of your blood stem cells.
Not every hospital has the technology or expertise for collecting blood stem cells. The procedure can only be carried out at a suitably certified hospital/clinic and fulfill the necessary conditions.
Most types of blood cancer can first be treated with chemotherapy, the aim of which is to simply destroy the cancer cells. Other forms of treatment can be used as well, such as radiation or antibody therapies, or a blood stem cell transplant.
For many patients, a blood stem cell donation is their last chance to beat blood cancer. These patients need a matching donor whose tissue characteristics (HLA characteristics) should match those of the patient 100 percent, if possible. To prepare for the transplant, the patient undergoes chemotherapy to suppress their own immune system, which helps to ensure the body does not reject the donation. After the transplant, the immune system gradually rebuilds itself.
With chemotherapy, the patient is given so-called cytostatic drugs to inhibit cell division and destroy the cancer cells. The treatment is performed in a hospital over several cycles, with drugs administered on one or more days followed by a break for the body to recover before the next cycle begins. The drugs can be given in the form of tablets, an injection, or an infusion.
Radiation therapy is used to specifically target tumors. The radiation is similar to that in X-rays but considerably higher-energy, which works by damaging the genetic makeup of the cancer cells. This stops them from dividing even further and kills them off. The process also affects healthy cells, but these can regenerate later on.
Antibodies are generated by immune cells in the body. They work by recognizing surface structures (antigens) of pathogens and attaching themselves to them. Any cells that are flagged in this way are identified by other immune cells as hostile and destroyed. More and more blood cancers can now be treated with artificially produced antibodies — especially non-Hodgkin lymphoma (NHL), but also chronic lymphocytic leukemia (CLL). They work on the basis of a 'lock and key' principle: the available antibodies are the key and work only on cancer cells with a matching lock, or antigen. If lock and key don’t match, the therapy will not work.
For many blood cancers, transplanting healthy blood stem cells is one possible form of treatment — and often the only chance of a cure. Whether or not a patient can undergo a blood stem cell transplant and what method would be used, depends on numerous factors including their particular diagnosis, age and state of health.
There are three different types of transplant: autologous, allogeneic, and syngeneic.
An autologous blood stem cell transplant uses the patient’s own stem cells, which are harvested from the blood and cleared of cancer cells. The patient is given chemotherapy, and their stem cells are returned to the body.
An allogeneic stem cell transplant uses the blood stem cells of a related or unrelated donor with the closest possible match of tissue characteristics.
A syngeneic transplant is the rarest form of stem cell transplant, as it involves using the cells of identical twins.
One crucial factor in the success of a blood stem cell transplant is the degree of match between the tissue characteristics (HLA) of donor and patient. Tissue characteristics are protein structures on the surfaces of all cells and occur in different combinations in every individual, much like fingerprints. The immune system recognizes from these protein structures whether or not a cell belongs to its own body. If it does, the cell is left intact. If not, it is destroyed. That is why it is essential to find a donor whose HLA characteristics match the patient’s as closely as possible. This way, the new immune system that develops from the donor’s stem cells will accept the patient’s own cells.
Because tissue characteristics are inherited, the best chance of finding a match between donor and patient is within families. Parents are normally only haploidentical, or ‘half-matching’ donors, as a child inherits half of its tissue characteristics from the mother and half from the father. The highest probability of a match is between siblings, which is why they are the first family members to be tested as potential donors.
If there are no matching donors in the patient’s family, the search continues with an attempt to find a compatible unrelated donor. Around the world, over 36 million people have now chosen to register as potential blood stem cell donors, over 10 million of which are within DKMS’s worldwide database. If no suitable donor is found there, the search is extended internationally.
DKMS-BMST needs monetary donations to further expand its database with new donors. Our mission is to ensure every patient battling with blood cancer and blood-related disorders gets a second chance at life. As a charitable organization sometimes, it becomes financially challenging to support these patients and this is where we seek your support to make our cause more impactful.
The deductions under Section 80G are the contributions that you have made to some charitable organizations. However, not all donations are eligible under this section.
DKMS-BMST is happy to issue receipts/confirmations for donations. Please provide your name and address. You will receive a successful notification after you complete your donation process. However, we’ll send you a receipt via email, if you fill in the donor details section carefully.
As per the revised tax exemption act, effective April 1, 2017, donations above Rs 500 to DKMS-BMST will be eligible for 50% tax exemption under Section 80G of the Income Tax Act. The exemption is calculated by reducing the donated amount from your taxable salary.
(Example: if your taxable income per year is Rs 200,000 and you make a donation of Rs 5,000 then your net taxable income will become Rs 197,500. Your tax will now be calculated on this new amount basis the prevailing tax rates)
There will be no cost to you. When a donor is matched with a patient, DKMS-BMST will cover the costs (including any travel, meals, lodging expenses or potential loss of salary). DKMS-BMST will also cover the costs for a companion to travel with you to the hospital. It is not necessary to use a donor’s own health insurance. Whilst it is extremely rare to require follow-up care, if it is ever needed, the donor’s costs will also be covered by DKMS-BMST. Other than that, we are not legally allowed to make any payments or rewards for the provision of blood stem cells for transplantation.